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  1. 2013.01.22 최명준 박사 주요이력 및 연구실적

최명준 박사 주요이력 및 연구실적

최명준박사 스토리/최명준 Profile 2013.01.22 19:32 Posted by 최명준박사의 P1P이야기 phytoLife

주요이력 및 연구실적

1) 성 명 : 최 명 준 (약사면허번호 제 30765)

2) 소속 및 직책 : (주) 피토스 대표이사


Edcational Background:

B. S.   in Department  of  Pharmaceutics, College  of Pharmacy,Pusan Univ.(1986), 약사면허 소지 (30765)

M. S.  in Department of  Biological Science, Korea Advanced Institute of Science and Technology  (KAIST) (1989)

Ph. D. in Department  of  Life Science  (Biological Science),  Korea Advanced Institute of Science  and Technology (KAIST) (1992)


Dissertation Titles:

M.  S.  Studies in the Formation and Properties of Polymeric Phospholipid

Ph. D.  Formation and Physicochemical Properties of Polymeric pH-Sensitive Liposomes


 Professional Experience:

-  Research and Teaching Assistant, Department of Biological Science, Korea Advanced Institute of Science Technology (1989 - 1992)

-  Project Researcher, Supported by the Ministry of Science and Technology (1987 - 1989)

-  Post Doc. fellowship, in Department of Life Science, Korea Advanced Institute of Science and Technology (1992 - 1993)

-  993-1995.12: 목암연구소 선임연구원

-  996-2001. 7: 목암연구소 책임연구원

-  2001-2002: 유전자 치료제  생물학적 제제 중앙약사심의 위원

-  2001.7-2001. 12: 두산기술원 객원 연구원

-  2001. 12-2005.2: 참존 생물소재연구소 수석연구원

-  2002. 3-2005.2: UCSF 피부과 객원 연구원

-  2005. 3- 2007. 7: 참존 생물소재연구소장

-  2006-present: 피부장벽학회 간행이사

-  2006-present: 산업자원부 생물의약품 생물화장품 기획 위원

-  2007. 7-2010. 8: 한국임상시험센터 센터장

-  2010. 5.-현재: 피토스 대표이사

-  2010. 10-현재: 글로벌코스메틱사업단 평가 자문위원


       Performed and Present Projects:

 1. Development of liposomes system targeted to cancer cells in vitro and in vivo (1991-1993)

 2. Development of targeting system to liver cells using galactose exposed liposomes (1993-1995)

 3. Development of Gag-ENV chimeric protein based HIV vaccine (1994-1996)

 4. Development of V3 peptide based HIV vaccine (1995-1997)

 5. Synthesis of PC containing myristic acid analogs for HIV therapy (1994-1995)

6. Development of liposomal adjuvant for cytotoxic T lymphocytes (CTL) in vivo (1994-1998)

7. Development of CTL based tumor vaccine (1997-1999)

8. Synthesis of New cationic lipids and development of gene therapy for liver cancer (1999-2001)

9. Stabilization of recombinant G-CSF protein with liposomes systems (2000-2001)

10. Preparation and development of liposomes system containing of high content phytosphingosine (2001. 6-2001.12, at Doosan Biotech)

11. Preparation and development of liposomes system containing of high content ceramide and N-acetyl phytosphingosine (2001. 6-2001.12, at Doosan Biotech)

12. In vitro skin penetration of caffeine formulation using human skin (2002, in UCSF)

13. In vivo skin permeation of liposomal methyl nicotinate cream (2002, in UCSF)

14. Antioxidant capacity test of cosmetic creams (2002, in UCSF)

15. Chemical induced protein secretion assay using callus method (2002, in UCSF)

NF-kB decoy (oligonucleotide) formulation and skin permeation assay (2003, finished in UCSF)

16. Evaluation of skin enhancers and retardants on the skin penetration (2004, in UCSF)

17. 나노입자를 이용한 경피흡수 촉진 시스템 개발 피부의약품으로의 적용 (2005-2006, 참존)

18. 항암약물 피부 전달을 통한 국소 건선치료제 개발 (2005-2011, 서울시 전략혁신 클러스터 사업)

19. 항암 T 세포 활성 억제제를 이용한 국소 건선 치료제 개발 (2005, 참존)

20. 면역조절을 통한 아토피 개선 원료의 탐색 (2005, 참존)

21. 면역조절을 통한 자극완화 물질의 개발 (2006, 참존)

22. 발효를 통한 고기능성 식품 의약품 소재  개발 (2005-2006, 참존)

23. 면역조절물질 함유 나노입자를 이용한 아토피 개선 치료제 개발 (2006-2009, 과기부 차세대성장동력 면역기능제어기술개발과제): 바이아토 아토킹 제품 판매

24. EGF 피부투과 촉진 제제 개발을 통한 화장품 개발 상처치료제 개발 (2006-2007, 참존 넥스젠)

25. 스트레스 해소, 신생혈관생성 촉진 물질을 이용한 탈모 예방 치료제 개발 (2007-2010, 피토스): 피토페시아 헤어부스팅 샴푸 피토페시아 헤어토닉 시판

26. 면역증강메비좀을 이용한 항암약물 전달체 개발 완료 


       Interesting Fields (현재 진행 향후 연구 관심분야)

-   나노 입자를 이용한 생리활성 물질의 피부투과 촉진 시스템 개발 피부의약품으로 적용: 생리활성 원료의 피부투과 촉진을 통해 효능 증진 부작용 감소의 개량 신약 개발

-     Bioadhesive film (patch and gel) 이용한 피부 투과형 의약품 개발

-     메비좀을 이용한 항암약물 전달 시스템 개발 국소 건선 치료제의 개발

-     피부면역질환 (아토피, 건선) 개선 치료제 개발

-     상처치유 소재 (EGF, small molecules) 개발 피부투과 촉진 제제화 연구

-     발모 육모 소재 개발 제제화 연구

-     면역증강 메비좀을 이용한 항암약물 전달체 적용


       Publications :

1.   U.H. Kim, E.S. Kim, M.J. Choi, and H. Kim. “Effect of surfactants on the stability of phosphatidylcholine vesicles” Korean J. Biochem. 24, 1-6, (1992)

2.   M.J. Choi, H.S. Han and H. Kim. "pH-sensitive liposomes containing polymerized phosphatidyl -ethanolamine and fatty acids" J. Biochem. 112, 694-699, (1992).

3.   M.J. Choi*, H.S. Cheong and H.M. Moon. "Structure and function of Liposomes" Saenghak nyusu 14(5), 265-272, (1994). * Corresponding author

4.   S.Y. Hong, J.E. Oh, M.J. Choi, J.H. Lee, B.K. Lee, H.M. Moon, K.H. Lee. “Identification and Characterization of Novel Antimicrobial Decapeptides Generated by Combinatorial Chemistry” Antimicrob. Agents Chemother.42(10) 2534-2541 (1998)

5.   L. Luo, Y. Li, J.S. Chang, T.Y. Kim, M.Y. Choi, H.S. Cheong, H. H. Kim, H. J. Ahn, M.K. Min, S.Y. Park, and C.Y. Kang. “Induction of V3-Specific Cytotoxic T lymphocytes Responses by HIV gag Particles Carrying Multiple Immunodominant V3 Epitopes of gp120” Virology 240, 316-325 (1998)

6.   J.S. Chang, M.J. Choi*, T.Y. Kim, S.Y. Cho, and H.S. Cheong. “Immunogenicity of synthetic HIV-1 V3 loop peptides by MPL adjuvanted pH-sensitive liposomes” Vaccine 17, 1540-1548 (1999) * Corresponding author

7.   J.S. Chang, M.J. Choi*, T.Y. Kim, G.J. Woo, S.I. Chung and H.S. Cheong. “Effect of Dehydration and Rehydration of the pH-Sensitive Liposomes Containing Chimeric gag-V3 Virus Like Particles on their Long-term Stability” Biotechnol. Bioprocess Eng. 4, 66-71 (1999) * Corresponding author

8.   J.S. Chang, M.J. Choi, H.S. Cheong and Kilhyoun Kim. “Development of Th1 mediated CD8+ effector T cells by vaccination with epitope peptides encapsulated in pH-sensitive liposomes” Vaccine, 2001, 19(27) 3608-3614.

9.   W.B. Park, H.K. Cheong, M.J. Choi. “Inhibition of tumor growth and metastasis by Korean mistletoe lectin is associated with apoptosis and antiangiogenesis” Cancer Biotherapy & Radiopharmaceuticals, 2001, 16: 439-447.

10.  S. Bian, J. Zheng, M.J. Choi, and D.D. Kim. “In vitro and In vivo studies of topical delivery system of genetisic acid in hairless mice” J. Kor. Pharm. Sci., 2002, 32: 161-164.

11.  M.J. Choi and J.S. Chang. “PH-sensitive liposomes as adjuvants for peptide antigens” Methods in Enzmology, 2003, 373: 127-136.

12.  H. Zhai, M.J. Choi, M. Arens-Corell, B.A. Neudecker, and H.I Maibach. “A rapid, acurate, and facile method to quantify the antioxidantive capacity of topical formualtions” Skin Research and Technology, 2003; 9:1-3.

13.  M.J. Choi and H.I Maibach. “Topical vaccination of DNA antigens: topical delivery of DNA antigens” Skin Pharmacol Appl Skin Phaysiol, 2003; 16 (5): 271-282.

14.  M.J. Choi and H.I. Maibach. “Effect of tape stripping on percutaneous penetration and topical vaccination” Exogenous Dermatology, 2003, 2: 262-269.

15.  M.J. Choi and H.I. Maibach. “Role of ceramides in skin stress: Ultraviolet light, tape stripping and crowding” Exogenous Dermatology, 2003, 2: 286-294.

16.  M.J. Choi, S.H. Kang, S. Kim, H. Cho, J.S. Chang, S.S. Kim and K.H. Lee “The interaction of an antimicrobial decapeptide with phospholipid vesicles”, Peptides, 2004, 25: 675-683.

17.  S.H. Oh, S.H. Kim, M.J. Choi, K.M. Kim and K.N. Kim. “The antibacterial effect of oral rinses containing phytosphingosine against oral microorganisms” The Journal of the Korea Research Society for Dental Materials, 2005, 32(4):  351-357

18.  MJ Choi and HI Maibach “Ceramides in barrier function of healthy and diseased skin” Am J Clin Dermatol, 2005, 6: 215-223.

19.  MJ Choi and HI Maibach “Ceramides in skin stress-Ultraviolet, Tape stripping, and Crowding” Cosmetics & Toiletries, 2005, 120: 46-52.

20.  H Zhai, S Behnam, MJ Choi and HI Maibach “Evaluation of the antioxidant capacity and preventive effects of a topical emulsion and its vehicle control on the skin response to UV exposure” Skin Pharmaco Physiol 2005; 18; 288-293

21.  MJ Choi and HI Maibach “Elastic vesicles as transdermal drug delivery systems, Int J Cosmetic Sci, 2005, 27: 1-11.

22.  MJ Choi and HI Maibach “Liposomes/niosomes as a drug delivery system” Skin Pharmacol Physiol, 2005, 18; 209-219.

23.  MJ Choi and HI Maibach “Ceramides in healthy and diseased skin” Cosmetics & Toiletries, 2006, 121(4): 24-29..

24.  M.J. Choi, J.H. Kim and H.I. Maibach. “Topical vaccination with lipid-based DNA complex” Current Drug Delivery, 2006, 3(1); 37-45.

25.  S.H. Oh, M.J. Choi, B.I. Kim, K.M. Kim and K.N. Kim. “Antibacterial effect of oral rinses containing phytosphingosine” Key Engineering Materials 2007, Vols 342-343, 941-944.


 Presentation:

1.    M. J. Choi, and H. Kim. "PH-sensitive liposomes consisted of polymeric phosphatidylethanolamine and fatty acids", 65th Annual Meeting of the Korea Chemical Society, (1990).

2.    M. J. Choi and H. Kim. “PH-sensitive polymeric liposomes consisted of phosphatidylethanolamine and fatty acids", presented at the Fall Meeting of the Korean Biochemical Society, (1990).

3.    M. J. Choi and H. Kim. "Novel targeting liposomes: Temperature and pH        -sensitive liposomes (I)", presented at the Spring Meeting of the Korean Biochemical Society, (1992).

4.    M. J. Choi, et al. "Novel targeting liposomes: Temperature and pH- sensitive liposomes (II)", presented at the fall conference on Biochemistry and Molecular Biology, (1993).

5.    J. S. Chang, M. J. Choi, et al.  "Targeting of galactocerebroside inserted liposomes to liver cell", presented at the fall conference on Biochemistry and Molecular Biology, (1993).

6.    S. Y. Cho, M. J. Choi, et al. "Binding assay system of CTL epitope peptides”, at the Spring Meeting of the Korean Biochemical Society, (1994).

7.    M. J. Choi et al. " Interaction of HIV-V3 peptides with liposomes (I)", presented at the Spring Meeting of the Korean Biochemical Society, (1994)

8.    M. J. Choi et al. " Interaction of HIV-V3 peptides with liposomes (II) ", presented at the Fall Meeting of the Korean Biochemical Society, (1994).

9.    S. W. Chi, M. J. Choi, et al. " 2D-NMR studies on the function and nonfunctional signal sequences of E. coli ribose binding protein ", presented at the Fall Meeting of the Korean Biochemical Society, (1994).

10.  M. J. Choi et al. "Immunogenicity of synthetic HIV-V3 loop peptides I : Humoral  immunity ", 6th Annual Meeting of the Korean Society for Molecular Biology, (1994).

11.  J. S. Chang, M. J. Choi, et al. " Immunogenicity of synthetic HIV-V3 loop peptides II : Cellular immunity", 6th Annual Meeting of the Korean Society for Molecular Biology, (1994).

12.  K. Y. Lee, M. J. Choi, et al. "Confirmation of N-protein peptide specific CTL from live Hantaan virus immunized mice", 30th Spring Meeting of the Korean Society for Immunology, (1995).

13.  T. Y. Kim, M. J. Choi, et al. "Generation of peptide specific CTL in immunized mice with Hantaan N-protein peptide encapsulated liposomes", 30th Spring Meeting of the Korean Society for Immunology, (1995).

14.  J. S. Chang, M. J. Choi, et al. "Generation of HIV loop specific humoral and cellular immunity", 30th Spring Meeting of the Korean Society for Immunology, (1995).

15.  M. J. Choi, et al. "Interaction of tenesin fragment peptide with liposomes (I)", presented at the Fall Meeting of the Korean Biochemical Society, (1995).

16.  M. J. Choi, et al. "Interaction of tenesin fragment peptide with liposomes (II)", presented at the Fall Meeting of the Korean Biochemical Society, (1995).

17.  L. Luo, M J. Choi, et al. "Induction of HIV-specific Cytotoxic T cell response by HIV Gag particle carrying immunodominant multiple V3 loop of GP120", presented at the American Society for Virology, (1996).

18.  M. J. Choi, et al. “Interaction of tenecin fragments with liposomes”. Presented at the Summer Meeting of the Korean Biophysical Society, (1996).

19.  S. Ghosh, R. Wester, M.J. Choi, S. Barbadillo, X. Hui, and H. Maibach. “Comparative study of in vitro cutaneous disposition of topical caffeine formulations in human skin: Enhanced penetration using novel liposomal caffeine formulation” American Academic Dermatology, 61st Annual Meeting, March 21-26, 2003

20.  Honbo Zhai, M.J. Choi and H.I. Maibach. “Antioxidative capacity of a topical emulsion versus its vehicle” 5th Las Vegas Dermatology Seminar, November 11-14, 2004

21.  S.H. Oh, S.H. Kim, M.J. Choi, K.M. Kim and K.N. Kim. “The antibacterial effect of oral rinses containing phytosphingosine” 아시아 예방치과학회, 2004. 12

22.  S.H. Oh, M.J. Choi, B.I. Kim, K.M. Kim and K.N. Kim. “Antibacterial effect of oral rinses containing phytosphingosine” 7th Asian Symposium on Biomedical Materials, Jeju-do, Korea, August 20-23, 2006.

23.  K.N Kim, M.J. Choi and J.H. Kim. “Production of the useful materials from liquid fermentation of soybean hull by Bacillus sp” 24th IFSCC Congress Osaka Japan, October 16-19, 2006


 Books:

1.   Development and Prospects of Immunotherapetics, 2001, Korea Patent Association

2.   Dermatotoxicology 6th and 7th edition, “Tape stripping method and stratum corneum”

3.   Percutaneous Absorption 4th edition, “Percutaneous penetration of oligonucleotide drugs”. “Topical vaccination of DNA antigens: topical delivery of DNA antigens” “Effect of tape stripping on the percutaneous absorption and topical vaccination”

4.   2006년도 산업 기술 동향 분석: 난치성 피부질환 치료제, 산업기술평가원

5.   Handbook of Cosmetic science and Technology 2nd edition, “Ceramides in barrier function of healthy and diseased skin” “Role of ceramides in skin stress: UV, tape stripping and crowding” in press

6.   Cosmeceuticals 2nd edition, “Liposomes/niosomes as a topical drug delivery system” in press


 Patents:

Patent Title

Filing No

Date of Filing

Nation

Process for preparation of liver targeting pH-sensitive liposomes

115418

1997.5.20

Korea

Process for preparation of stability improved pH-sensitive liposomes

115419

1997.5.20

Korea

Process for preparation of temperature and pH sensitive liposomes

115420

1997. 5.20

Korea

Human immunomodulating CTL peptides against a HCV (I)

137153

1998.2.4

Korea

Human immunomodulating CTL peptides against a HBV

137617

1998. 2.10

Korea

Preparation of pH-sensitive liposomes containing of immunodominant HIV peptides

154576

1998.7.10

Korea

Human immunomodulating CTL peptides against a Hantaan virus

166425

1998.9.23

Korea

PH-Sensitive liposomes containing of multivalent CTL polypeptides derived from various virus origin

173364

1998.10.29

Korea

PH-sensitive liposomes containing of HCV human CTL epitope peptides

173365

1998.10.29

Korea

PH-Sensitive liposomes containing of HBV human CTL epitope peptides

173366

1998.10.29

Korea

PH-Sensitive liposomes containing of Hantaan virus human CTL epitope peptides

178422

1998.11.23

Korea

PH-sensitive liposomes containing of human CTL epitope peptide derived from HBV X-protein

189701

1999.1.18

Korea

Human immunomodulating CTL peptides against a HCV (II)

190910

1999.1.21

Korea

Human immunomodulating CTL peptides derived from HBV X protein

194283

1999.2.8

Korea

Liposomes comprising peptide antigens derived from X-protein of HBV

00010

 

PCT/KR98

Liposomes containing of protein antigens derived from H,pylori

207289

1994.4.12

Korea

Assay system for antibiotics using liposomes

 

1999.4.9

Korea

항암활성을 지닌 파이토스핑고신 유도체

 

 

국제특허

7-디하이드로콜레스테롤 사이클로덱스트린의 포접복합체, 이를 포함하는 화장료 조성물 7-디하이드로콜레스테롤의 안정화 방법

0473716

2005. 2.18

Korea

피부 미백 주름 개선용 활성 추출물 제조 방법

0074716

2005. 7. 19

Korea

피부보호용 디이노코커스 라디오두란스 세포막 추출물 이를 포함하는 피부 외용제

0002585

2006. 1. 12

Korea

복분자 발효물을 이용한  피부 질환 치료용 조성물

등록

 

Korea

탈모의 예방, 치료 또는 육모용 조성물

등록

1003532

Korea

국소투여용 나노에멀젼

출원

2008

Korea

트리메칠피토스핑고신 유도체를 함유한 건선 예방 치료용 조성물

출원

2008

Korea

Composition for the prevention and treatment of alopecia or for hair growth

출원

2009

PCT/KR2009/004254

 



 

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