Story Of P1P :: 2012유럽피부모발학회 참가/P1P(피토스핑고신포스페이트)의 모발성장 유도 기전

중앙대학교의과대학 김범준교수팀이 스페인에서 개최된 "2012년유럽피부모발학회"에 참가하여 피토스핑고신포스페이트(P1P)의 모발성장유도에 관련한 연구결과를 발표하였습니다.

Induction of hair growth by phytosphingosine-1-phosphate in C3H/HeJ mice model

Hyun Kyu Kim, Yun Young Lim, Hyeong Mi Kim, Yang Won Lee1, Chong Hyun Won2, Chang Hun Huh3, Chang Kwun Hong, Beom Joon Kim*
Department of Dermatology, Chung-Ang University, College of Medicine, Seoul, Korea
1 Department of Dermatology, Konkuk University, College of Medicine, Seoul, Korea
2Department of Dermatology, Asan Medical Center, University of Ulsan College of medicine, Seoul, Korea
3Department of Dermatology, Seoul National University Bundang hospital, Seongnam, Gyeonggi, Korea
*E-mail: beomjoon@unitel.co.kr
*Phone number: +82-2-6299-3082


Sphingosine-1-phosphate (S1P) which is stored in and released from platelet seems to play various roles physiologically. S1P through S1P receptor induces angiogenesis which is one of the major therapeutic strategies of hair growth. Phytosphingosine-1-phosphate (PhS1P), a S1P receptor agonist, has been shown to have angiogenic activity. We investigated the efficacy of PhS1P to hair growth in C3H/HeJ mice. After setting same hair cycle using a grainer and hair loss cream, the mice were divided into 5 groups: normal hair (no treatment), a vehicle material of PhS1P, a positive control of 3% minoxidil, treatment of PhS1P, and cyclic PhS1P group. The efficacy was assessed by dermoscope and histologic analysis was made by hematoxylin and eosin staining. We observed that topical application of 3% minoxidil, PhS1P and cyclic PhS1P solution promoted hair growth earlier and faster than the negative control group. PhS1P group showed better hair growth effect than cyclic PhS1P group. And increased expression of Wnt3a, Wnt5a, and mice hair growth-related molecules was observed in PhS1P and cyclic PhS1P group. These findings suggest that PhS1P could be one of treatment options for hair growth. This study was supported by a Korea Research Foundation Grant funded by the Korea Government (2010-0021960).


혈소판에서 분비되는 Sphingosine-1- phosphate (S1P) 생리학적으로 다양한 역할을 합니다. S1P S1P수용체를 통해 새로운 모세혈관생성을 유도합니다. 이는 머리카락  성장의  주요한 치료 전략 중 하나입니다.

Phytosphingosine-1- phosphate (PhS1P or P1P)는 S1P 수용체 동일하게 작용하며 신생혈관생성 활동을 합니다.

 

우리는 C3H/HeJ 마우스의 모발 성장에 PhS1P 효능을 연구하였습니다.

3 % minoxidil 국소 응용 프로그램과 비교 관찰한 결과 P1P(PhS1P) cyclic PhS1P 솔루션은 대조군에 비해 모발성장을 빠르게 촉진하고,  PhS1P 그룹은 cyclic PhS1P 그룹보다 빠른 머리카락의 성장 효과를 보여주었다. 그리고 Wnt3a, Wnt5a 신호가 증가하고마우스 모발성장의 관련 분자가  PhS1P 순환 PhS1P 그룹에서 관찰되었습니다.

 

이러한 연구 결과로 볼때 PhS1P(P1P)는 모발의 성장에 대한 치료 옵션 하나가 있다고 제안합니다. 연구는 대한민국정부가 자금을 지원한 한국 학술 진흥 재단 에의해 지원되었습니다


발표자료보기 : https://docs.google.com/file/d/0B1fk2h65xEgAOXB6WExxV2FPWE0/edit?usp=sharing

 



 

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